[Skip to the guide](#main) [NXT LVL](/) A peptide reading guide [The lineup](/#lineup) [Compare](/compare/) [Questions](/faq/) [About](/about/) ### Menu [The lineup](/#lineup) [Compare](/compare/) [Questions](/faq/) [About](/about/) [NXT LVL](/) Compare GROWTH-HORMONE PEPTIDES / SIDE-BY-SIDE # Same hormone system. Different questions. Compare growth-hormone peptides: short chains of protein building blocks linked to hormone signals. See what each is, where the evidence stops and what needs medical review. This is a reading aid, with no ranking or personal recommendations. [Start a Promise Peptides visit for muscle & recovery](https://mypromise.com/solutions/muscle-recovery?utm_source=nxtlvl&utm_medium=affiliate&utm_campaign=topic&utm_content=opening) NXT LVL may earn money when readers become Promise patients. Promise prescribes now. A licensed U.S. provider reviews each request and decides whether to prescribe. Not everyone qualifies. Compounded medicines are made to order and are not FDA-approved. U.S. patients only. Availability varies by state and by treatment. Promise does not offer care outside the U.S. NXT LVL / FIELD NOTES Evidence before expectations ## Read the columns as questions. A secretagogue prompts a gland to release a hormone. These peptides use signals linked to growth hormone, made by the pituitary gland beneath the brain. They are not growth hormone itself. The shared pathway does not give them the same evidence or legal status. Compounded means prepared to order. FDA, the U.S. drug regulator, has not approved compounded medicines. The pharmacy's ingredient rules apply separately from a provider's decision about a person. ## The field notes. ### CJC-1295 What it is A lab-made copy of the brain's growth-hormone signal. DAC is an added chemical part; forms with it and without it are different ingredients. Where the evidence stands Small studies in healthy adults appear to use the DAC form. No FDA approval. Current routine raw-ingredient compounding requirements are not met. Question for review Which exact form is named, and does the evidence match it? [Read the CJC-1295 note](/cjc-1295/) ### Ipamorelin What it is A lab-made peptide using the signal pathway for ghrelin, a hormone linked to hunger. Where the evidence stands Published human studies involved healthy men or bowel-surgery patients. No FDA approval. Current routine raw-ingredient compounding requirements are not met. Question for review What human evidence addresses the proposed use, and what are the ingredient barriers? ### CJC-1295 + ipamorelin What it is A pairing of two separate hormone signals. Where the evidence stands The pair is not FDA-approved. Single-ingredient research does not establish training results or safety for the combination. Question for review Which CJC-1295 form is included, and what evidence actually studied the pair? [Read the CJC-1295 + ipamorelin note](/cjc1295-ipamorelin/) ### Sermorelin What it is A short lab-made copy of part of the brain's growth-hormone signal. Where the evidence stands The earlier approved products are discontinued. Versions prepared to order are not FDA-approved. Adult studies were small and short. Question for review What is the intended use, and what evidence supports it for this person? [Read the Sermorelin note](/sermorelin/) ### Tesamorelin What it is A lab-made version of that brain signal with an added chemical part. Where the evidence stands An approved product has a specific use in adults with HIV, a virus that affects the immune system, and a related body-fat disorder. Compounded versions are not FDA-approved. Special federal rules also prevent pharmacies from making their own copies of tesamorelin. Question for review Is this finished product FDA-approved for the person's medical condition? [Read the Tesamorelin note](/tesamorelin/) ## Tesamorelin + ipamorelin. This name describes a combination, not the approved tesamorelin product. Approval of a single finished medicine does not extend to a blend with another peptide. Ipamorelin adds its own evidence gaps and FDA safety concerns. Promise lists these options for provider review. A licensed U.S. provider decides whether to prescribe. The listing does not change FDA status or the rules for the exact ingredient. The pairing has no established approval through tesamorelin's single-product approval. [Start a Promise Peptides visit for tesamorelin + ipamorelin](https://mypromise.com/products/tesamorelin-ipamorelin?utm_source=nxtlvl&utm_medium=affiliate&utm_campaign=topic&utm_content=tesamorelin-ipamorelin) NXT LVL may earn money when readers become Promise patients. Promise lists tesamorelin + ipamorelin. A licensed U.S. provider decides; not everyone qualifies. FDA still lists ipamorelin acetate in Category 2, its safety-concern group, for 503B only: larger compounding facilities. This is not a 503A Category 2 listing. ## FDA groups need the full context. FDA's page current as of April 22, 2026 lists CJC-1295 among withdrawn nominations. It lists ipamorelin acetate both there and in Category 2, a safety-concern group for larger compounding facilities. A withdrawn nomination is not clearance, and FDA gives no individual withdrawal dates. A page on a commercial website cannot change those facts. The beginner questions explain the difference between a product listing, a prescription decision and lawful pharmacy preparation. [Read the beginner questions](/faq/) ## What FDA's safety concerns include. ### CJC-1295 FDA reports serious reactions linked to CJC-1295, including a faster heart rate and flushing. It also notes dizziness and low blood pressure. FDA warns that the immune system may react to the peptide. ### Ipamorelin FDA is concerned that injected ipamorelin could trigger an immune reaction. No human study has checked its safety when injected under the skin. In a study that gave ipamorelin into a vein, two patients died after complications of cancer surgery. FDA says it is unclear whether ipamorelin played a part. ## The single ingredient. Promise lists these options for provider review. A licensed U.S. provider decides whether to prescribe. The listing does not change FDA status or the rules for the exact ingredient. [Start a Promise Peptides visit for ipamorelin](https://mypromise.com/products/ipamorelin?utm_source=nxtlvl&utm_medium=affiliate&utm_campaign=topic&utm_content=ipamorelin) NXT LVL may earn money when readers become Promise patients. Promise lists ipamorelin. A licensed U.S. provider decides; not everyone qualifies. FDA still lists ipamorelin acetate in Category 2, its safety-concern group, for 503B only: larger compounding facilities. This is not a 503A Category 2 listing. ## Source notes - [FDA review of CJC-1295](https://www.fda.gov/media/183819/download) - [FDA review of ipamorelin](https://www.fda.gov/media/182088/download) - [FDA peptide ingredient safety listings](https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks) - [FDA records for sermorelin](https://api.fda.gov/drug/drugsfda.json?search=openfda.generic_name:%22sermorelin%22+OR+products.active_ingredients.name:%22SERMORELIN%22) - [Current approved tesamorelin drug label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=839334d3-8c1d-4c26-9036-2ab524a6ea75) ## Put the next step in licensed hands. A Promise visit starts a request for review. A licensed U.S. provider decides whether to prescribe. Not everyone qualifies, and no particular treatment is promised. [Start a Promise Peptides visit for muscle & recovery](https://mypromise.com/solutions/muscle-recovery?utm_source=nxtlvl&utm_medium=affiliate&utm_campaign=topic&utm_content=closing) NXT LVL may earn money when readers become Promise patients. Promise prescribes these peptides now through licensed U.S. providers. A provider reviews every request and decides. Not everyone qualifies. U.S. patients only. Availability varies by state and by treatment. Promise does not offer care outside the U.S. NXT LVL Read the facts. Keep your perspective. [Compare](/compare/) [Questions](/faq/) [About](/about/) [References](/references/) [Contact](/contact/) [Promise Peptides: start a peptide visit](https://mypromise.com/products?utm_source=nxtlvl&utm_medium=affiliate&utm_campaign=topic&utm_content=footer) NXT LVL may earn money when readers become Promise patients. NXT LVL is not affiliated with any company that has used the name NXT LVL Peptides or Next Level Peptides. NXT LVL is a reading guide, not a clinic, pharmacy or seller, and these pages cannot give personal medical advice. Promise prescribes peptides now through licensed U.S. providers. A provider reviews every request and decides. Not everyone qualifies. U.S. patients only. Availability varies by state and by treatment. Promise does not offer care outside the U.S. Medications are prepared by licensed U.S. compounding pharmacies. Compounded medications are not FDA-approved. A pharmacy checks the exact ingredient and applicable rules before preparation. Promise is LegitScript-certified. This is not an FDA approval of Promise or of a medicine.