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GROWTH-HORMONE PEPTIDES / SIDE-BY-SIDE

Same hormone system. Different questions.

Compare growth-hormone peptides: short chains of protein building blocks linked to hormone signals. See what each is, where the evidence stops and what needs medical review. This is a reading aid, with no ranking or personal recommendations.

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Promise prescribes now. A licensed U.S. provider reviews each request and decides whether to prescribe. Not everyone qualifies. Compounded medicines are made to order and are not FDA-approved.

U.S. patients only. Availability varies by state and by treatment. Promise does not offer care outside the U.S.

NXT LVL / FIELD NOTESEvidence before expectations

Read the columns as questions.

A secretagogue prompts a gland to release a hormone. These peptides use signals linked to growth hormone, made by the pituitary gland beneath the brain. They are not growth hormone itself. The shared pathway does not give them the same evidence or legal status.

Compounded means prepared to order. FDA, the U.S. drug regulator, has not approved compounded medicines. The pharmacy's ingredient rules apply separately from a provider's decision about a person.

The field notes.

CJC-1295

What it is
A lab-made copy of the brain's growth-hormone signal. DAC is an added chemical part; forms with it and without it are different ingredients.
Where the evidence stands
Small studies in healthy adults appear to use the DAC form. No FDA approval. Current routine raw-ingredient compounding requirements are not met.
Question for review
Which exact form is named, and does the evidence match it?
Read the CJC-1295 note

Ipamorelin

What it is
A lab-made peptide using the signal pathway for ghrelin, a hormone linked to hunger.
Where the evidence stands
Published human studies involved healthy men or bowel-surgery patients. No FDA approval. Current routine raw-ingredient compounding requirements are not met.
Question for review
What human evidence addresses the proposed use, and what are the ingredient barriers?

CJC-1295 + ipamorelin

What it is
A pairing of two separate hormone signals.
Where the evidence stands
The pair is not FDA-approved. Single-ingredient research does not establish training results or safety for the combination.
Question for review
Which CJC-1295 form is included, and what evidence actually studied the pair?
Read the CJC-1295 + ipamorelin note

Sermorelin

What it is
A short lab-made copy of part of the brain's growth-hormone signal.
Where the evidence stands
The earlier approved products are discontinued. Versions prepared to order are not FDA-approved. Adult studies were small and short.
Question for review
What is the intended use, and what evidence supports it for this person?
Read the Sermorelin note

Tesamorelin

What it is
A lab-made version of that brain signal with an added chemical part.
Where the evidence stands
An approved product has a specific use in adults with HIV, a virus that affects the immune system, and a related body-fat disorder. Compounded versions are not FDA-approved. Special federal rules also prevent pharmacies from making their own copies of tesamorelin.
Question for review
Is this finished product FDA-approved for the person's medical condition?
Read the Tesamorelin note

Tesamorelin + ipamorelin.

This name describes a combination, not the approved tesamorelin product. Approval of a single finished medicine does not extend to a blend with another peptide. Ipamorelin adds its own evidence gaps and FDA safety concerns.

Promise lists these options for provider review. A licensed U.S. provider decides whether to prescribe. The listing does not change FDA status or the rules for the exact ingredient.

Start a Promise Peptides visit for tesamorelin + ipamorelin

NXT LVL may earn money when readers become Promise patients.

Promise lists tesamorelin + ipamorelin. A licensed U.S. provider decides; not everyone qualifies. FDA still lists ipamorelin acetate in Category 2, its safety-concern group, for 503B only: larger compounding facilities. This is not a 503A Category 2 listing.

FDA groups need the full context.

FDA's page current as of April 22, 2026 lists CJC-1295 among withdrawn nominations. It lists ipamorelin acetate both there and in Category 2, a safety-concern group for larger compounding facilities. A withdrawn nomination is not clearance, and FDA gives no individual withdrawal dates.

A page on a commercial website cannot change those facts. The beginner questions explain the difference between a product listing, a prescription decision and lawful pharmacy preparation.

Read the beginner questions

What FDA's safety concerns include.

CJC-1295

FDA reports serious reactions linked to CJC-1295, including a faster heart rate and flushing. It also notes dizziness and low blood pressure. FDA warns that the immune system may react to the peptide.

Ipamorelin

FDA is concerned that injected ipamorelin could trigger an immune reaction. No human study has checked its safety when injected under the skin.

In a study that gave ipamorelin into a vein, two patients died after complications of cancer surgery. FDA says it is unclear whether ipamorelin played a part.

Promise lists these options for provider review. A licensed U.S. provider decides whether to prescribe. The listing does not change FDA status or the rules for the exact ingredient.

Start a Promise Peptides visit for ipamorelin

NXT LVL may earn money when readers become Promise patients.

Promise lists ipamorelin. A licensed U.S. provider decides; not everyone qualifies. FDA still lists ipamorelin acetate in Category 2, its safety-concern group, for 503B only: larger compounding facilities. This is not a 503A Category 2 listing.

Put the next step in licensed hands.

A Promise visit starts a request for review. A licensed U.S. provider decides whether to prescribe. Not everyone qualifies, and no particular treatment is promised.

Start a Promise Peptides visit for muscle & recovery

NXT LVL may earn money when readers become Promise patients.

Promise prescribes these peptides now through licensed U.S. providers. A provider reviews every request and decides. Not everyone qualifies.

U.S. patients only. Availability varies by state and by treatment. Promise does not offer care outside the U.S.